Renal insufficiency in Ghanaian HIV infected patients: need for dose adjustment
Identifieur interne : 000565 ( Main/Exploration ); précédent : 000564; suivant : 000566Renal insufficiency in Ghanaian HIV infected patients: need for dose adjustment
Auteurs : Wkba Owiredu [Ghana] ; L. Quaye [Ghana] ; N. Amidu [Ghana] ; O. Addai-Mensah [Ghana]Source :
- African Health Sciences [ 1680-6905 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (effets indésirables), Agents antiVIH (usage thérapeutique), Calcul des posologies, Créatinine (sang), Femelle, Ghana (épidémiologie), Humains, Infections à VIH (ethnologie), Infections à VIH (traitement médicamenteux), Insuffisance rénale (ethnologie), Insuffisance rénale (physiopathologie), Marqueurs biologiques (sang), Modèles linéaires, Mâle, Numération des lymphocytes CD4, Population d'origine africaine, Prévalence, Taux de filtration glomérulaire (physiologie), Thérapie antirétrovirale hautement active (effets indésirables), Valeur prédictive des tests, Études cas-témoins, Études transversales.
- MESH :
- effets indésirables : Agents antiVIH, Thérapie antirétrovirale hautement active.
- ethnologie : Infections à VIH, Insuffisance rénale.
- physiologie : Taux de filtration glomérulaire.
- physiopathologie : Insuffisance rénale.
- sang : Créatinine, Marqueurs biologiques.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- épidémiologie : Ghana.
- Adulte, Adulte d'âge moyen, Calcul des posologies, Femelle, Humains, Modèles linéaires, Mâle, Numération des lymphocytes CD4, Population d'origine africaine, Prévalence, Valeur prédictive des tests, Études cas-témoins, Études transversales.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, African Continental Ancestry Group, Anti-HIV Agents (adverse effects), Anti-HIV Agents (therapeutic use), Antiretroviral Therapy, Highly Active (adverse effects), Biomarkers (blood), CD4 Lymphocyte Count, Case-Control Studies, Creatinine (blood), Cross-Sectional Studies, Drug Dosage Calculations, Female, Ghana (epidemiology), Glomerular Filtration Rate (physiology), HIV Infections (drug therapy), HIV Infections (ethnology), Humans, Linear Models, Male, Middle Aged, Predictive Value of Tests, Prevalence, Renal Insufficiency (ethnology), Renal Insufficiency (physiopathology).
- MESH :
- chemical , adverse effects : Anti-HIV Agents.
- chemical , blood : Biomarkers, Creatinine.
- chemical , therapeutic use : Anti-HIV Agents.
- geographic , epidemiology : Ghana.
- adverse effects : Antiretroviral Therapy, Highly Active.
- drug therapy : HIV Infections.
- ethnology : HIV Infections, Renal Insufficiency.
- physiology : Glomerular Filtration Rate.
- physiopathology : Renal Insufficiency.
- Adult, African Continental Ancestry Group, CD4 Lymphocyte Count, Case-Control Studies, Cross-Sectional Studies, Drug Dosage Calculations, Female, Humans, Linear Models, Male, Middle Aged, Predictive Value of Tests, Prevalence.
Abstract
Antiretrovirals (ARVs) could lead to clinically significant nephrotoxicity and as such will require dose adjustments in the presence of renal insufficiency.
To explore renal function estimating equations as alternatives for glomerular filtration rate (GFR) measurement in a stable cohort of HIV-infected patients.
In estimating renal insufficiency in Ghanaian HIV-infected patients, GFR for 276 HAART-naïve patients and 166 patients on HAART was estimated with the Cockcroft-Gault, 4v-MDRD and CKD-EPI estimating equations.
Females outnumbered males by 3 to 1 in the HAART-naïve group and 4 to 1 in subjects on HAART. The prevalence of renal insufficiency calculated with the Cockcroft-Gault, 4v-MDRD and CKD-EPI equations was 8.7%, 9.1% and 8.7% in HAART-naïve patients; 14.5%, 12.6% and 12.6% in patients on HAART; 7.7%, 11.5% and 11.5% in HAART-naïve males; 10.8%, 8.1% and 8.1% in males on HAART; 9.1%, 8.0% and 7.5% in HAART-naïve females and 15.5%, 14.0% and 14.0% in females on HAART. The CKD-EPI equation yielded lower bias when compared to the Cockcroft-Gault and 4v-MDRD equations.
Renal insufficiency is not uncommon among HIV infected Ghanaian patients. A significant proportion (10 to 11%) will require ARV dose adjustment at the time of initiating therapy or sometime during on-going therapy.
Url:
DOI: 10.4314/ahs.v13i1.14
PubMed: 23658575
PubMed Central: 3645095
Affiliations:
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Quaye</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea> Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Amidu, N" sort="Amidu, N" uniqKey="Amidu N" first="N" last="Amidu">N. Amidu</name><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Medical Laboratory Technology, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea> Department of Medical Laboratory Technology, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Addai Mensah, O" sort="Addai Mensah, O" uniqKey="Addai Mensah O" first="O" last="Addai-Mensah">O. 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use)</term><term>Antiretroviral Therapy, Highly Active (adverse effects)</term><term>Biomarkers (blood)</term><term>CD4 Lymphocyte Count</term><term>Case-Control Studies</term><term>Creatinine (blood)</term><term>Cross-Sectional Studies</term><term>Drug Dosage Calculations</term><term>Female</term><term>Ghana (epidemiology)</term><term>Glomerular Filtration Rate (physiology)</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (ethnology)</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prevalence</term><term>Renal Insufficiency (ethnology)</term><term>Renal Insufficiency (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agents antiVIH (effets indésirables)</term><term>Agents antiVIH (usage thérapeutique)</term><term>Calcul des posologies</term><term>Créatinine (sang)</term><term>Femelle</term><term>Ghana (épidémiologie)</term><term>Humains</term><term>Infections à VIH (ethnologie)</term><term>Infections à VIH (traitement médicamenteux)</term><term>Insuffisance rénale (ethnologie)</term><term>Insuffisance rénale (physiopathologie)</term><term>Marqueurs biologiques (sang)</term><term>Modèles linéaires</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Population d'origine africaine</term><term>Prévalence</term><term>Taux de filtration glomérulaire (physiologie)</term><term>Thérapie antirétrovirale hautement active (effets indésirables)</term><term>Valeur prédictive des tests</term><term>Études cas-témoins</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Creatinine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antiretroviral Therapy, Highly Active</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Agents antiVIH</term><term>Thérapie antirétrovirale hautement active</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Infections à VIH</term><term>Insuffisance rénale</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>HIV Infections</term><term>Renal Insufficiency</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Taux de filtration glomérulaire</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Glomerular Filtration Rate</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Insuffisance rénale</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Renal Insufficiency</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Créatinine</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>African Continental Ancestry Group</term><term>CD4 Lymphocyte Count</term><term>Case-Control Studies</term><term>Cross-Sectional Studies</term><term>Drug Dosage Calculations</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prevalence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Calcul des posologies</term><term>Femelle</term><term>Humains</term><term>Modèles linéaires</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Population d'origine africaine</term><term>Prévalence</term><term>Valeur prédictive des tests</term><term>Études cas-témoins</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Antiretrovirals (ARVs) could lead to clinically significant nephrotoxicity and as such will require dose adjustments in the presence of renal insufficiency.</p></sec><sec><title>Objective</title><p>To explore renal function estimating equations as alternatives for glomerular filtration rate (GFR) measurement in a stable cohort of HIV-infected patients.</p></sec><sec sec-type="method"><title>Method</title><p>In estimating renal insufficiency in Ghanaian HIV-infected patients, GFR for 276 HAART-naïve patients and 166 patients on HAART was estimated with the Cockcroft-Gault, 4v-MDRD and CKD-EPI estimating equations.</p></sec><sec sec-type="results"><title>Results</title><p>Females outnumbered males by 3 to 1 in the HAART-naïve group and 4 to 1 in subjects on HAART. The prevalence of renal insufficiency calculated with the Cockcroft-Gault, 4v-MDRD and CKD-EPI equations was 8.7%, 9.1% and 8.7% in HAART-naïve patients; 14.5%, 12.6% and 12.6% in patients on HAART; 7.7%, 11.5% and 11.5% in HAART-naïve males; 10.8%, 8.1% and 8.1% in males on HAART; 9.1%, 8.0% and 7.5% in HAART-naïve females and 15.5%, 14.0% and 14.0% in females on HAART. The CKD-EPI equation yielded lower bias when compared to the Cockcroft-Gault and 4v-MDRD equations.</p></sec><sec sec-type="conclusion"><title>Conclusion</title><p>Renal insufficiency is not uncommon among HIV infected Ghanaian patients. A significant proportion (10 to 11%) will require ARV dose adjustment at the time of initiating therapy or sometime during on-going therapy.</p></sec></div></front></TEI><affiliations><list><country><li>Ghana</li></country></list><tree><country name="Ghana"><noRegion><name sortKey="Owiredu, Wkba" sort="Owiredu, Wkba" uniqKey="Owiredu W" first="Wkba" last="Owiredu">Wkba Owiredu</name></noRegion><name sortKey="Addai Mensah, O" sort="Addai Mensah, O" uniqKey="Addai Mensah O" first="O" last="Addai-Mensah">O. Addai-Mensah</name><name sortKey="Amidu, N" sort="Amidu, N" uniqKey="Amidu N" first="N" last="Amidu">N. Amidu</name><name sortKey="Quaye, L" sort="Quaye, L" uniqKey="Quaye L" first="L" last="Quaye">L. Quaye</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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